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The principal cytochrome P450 isoenzyme associated seems to be CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Approximately 85% of the oral dose seems during the urine within 24 hours of administration, most since the glucuronide conjugate, with smaller amounts of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity data.Because of